P-134: Anti Fertility Effects of Amaranthus Caudatus Extract in Female Rats

Background: Persistent oral administration of Amaranthus extract could decrease contractile response and enhance relaxation response in aortic tissue of diabetic rat through affecting endothelial related agents. This may be beneficial in prevention of long-term vascular complications of diabetes. Materials and Methods: In this exprimental study, Amaranthus caudatus rats (160-220 g) were used in three experiments. In each experiment, animals were divided into two subgroups (n=10): control group which received distilled water (2 cc/kg) and case group which received herb extract (100 mg/kg) intra-peritoneally. In the first experiment, animals received single dose of extract or DW. In the second experiment, female rats received extract or DW in the perimplantation period during day 1 to 5 of pregnancy and day 5 to 7 of pregnancy in the third experiment. Implantation sites and neonates were counted in all the three experiments. Results: All the three experiments showed significant differences between control and case groups in implantation sites and neonates number. These differences were more prominent in the first and third experiment. Conclusion: Amaranthus caudatus extract showed anti fertility effect in female rats.